Nexium contains a medicine called esomeprazole. This belongs to a group of medicines called ‘proton pump inhibitors’. They work by reducing the amount of acid that your stomach produces.

Nexium (Esomeprazole) Tablets

Nexium (Esomeprazole) Tablet 20mg

includes free private prescription
includes free private prescription
includes free private prescription

Nexium (Esomeprazole) Tablet 40mg

includes free private prescription
includes free private prescription
includes free private prescription


Adults and young people aged 12 years and above

  • ‘Gastro-oesophageal reflux disease’ (GORD). This is where acid from the stomach escapes into the gullet (the tube which connects your throat to your stomach) causing pain, inflammation and heartburn.
  • Ulcers in the stomach or upper part of the gut (intestine) that are infected with bacteria called ‘Helicobacter pylori’. If you have this condition, your doctor may also prescribe antibiotics to treat the infection and allow the ulcer to heal.


  • Stomach ulcers caused by medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Nexium can also be used to stop stomach ulcers from forming if you are taking NSAIDs.
  • Too much acid in the stomach caused by a growth in the pancreas (Zollinger-Ellison syndrome).
  • Prolonged treatment after prevention of rebleeding of ulcers with intravenous Nexium.
Always take Nexium exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

  • Nexium gastro-resistant tablets are not recommended for children less than 12 years old.
  • If you are taking this medicine for a long time, your doctor will want to monitor you (particularly if you are taking it for more than a year).
  • If your doctor has told you to take this medicine as and when you need it, tell your doctor if your symptoms change.
Like all medicines, Nexium can cause side effects, although not everybody gets them.

If you notice any of the following serious side effects, stop taking Nexium and contact a doctor immediately:

  • Sudden wheezing, swelling of your lips, tongue and throat or body, rash, fainting or difficulties in swallowing (severe allergic reaction).
  • Reddening of the skin with blisters or peeling. There may also be severe blisters and bleeding in the lips, eyes, mouth, nose and genitals. This could be ‘Stevens-Johnson syndrome’ or ‘toxic epidermal necrolysis’.
  • Yellow skin, dark urine and tiredness which can be symptoms of liver problems.

These effects are rare, affecting less than 1 in 1,000 people.

Take special care with Nexium

Check with your doctor or pharmacist before taking Nexium if:

  • You have severe liver problems.
  • You have severe kidney problems.

Nexium may hide the symptoms of other diseases. Therefore, if any of the following happen to you before you start taking Nexium or while you are taking it, talk to your doctor straight away:

  • You lose a lot of weight for no reason and have problems swallowing.
  • You get stomach pain or indigestion.
  • You begin to vomit food or blood.
  • You pass black stools (blood-stained faeces).

Medical Advice

Please refer to the articles below to find out more information, medical guidance and advice from our doctors on how to best treat the condition.
Learn about available treatments, symptoms, side effects and what you can do to prevent it.

Causes of Acid Reflux
It is now known that stomach acid is not actually the root cause of acid reflux. The main cause of heartburn and GORD is acid entering the oesophagus…
Read more
Acid Reflux Symptoms
Acid reflux is a fairly common condition whereby the contents of the stomach acid and other stomach content rise back up into the oesophagus…
Read more